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Cofactor brings genomic expertise to help save the northern white rhino from extinction

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What would it feel like to be the last “one” on earth? Sudan is the last male northern white rhino on the face of planet and he is surrounded by armed guards 24 hours a day. The guards and dogs that protect him are the only other organisms he interacts with everyday.

 In some Asian cultures, it’s believed that rhino horns can cure ailments, and this has led to aggressive poaching of the species. Poaching has driven the white rhino population from approximately 2000 animals in the 1960’s down to just 4 today.

The Northern White Rhino is extremely endangered. Sudan is 42-years-old (ancient in rhino years) and lives at the Ol Pejeta Conservancy in Kenya with two female white rhinos, Fatu and Najin, who are 15 and 25 years old. The remaining female lives at the San Diego Zoo.

White Rhinoceros (Artistic processing)

White Rhinoceros

You might think with three females and one male remaining, there’s still a chance of natural pregnancy, but a number of factors make it impossible.

For example, you could attempt a surrogate pregnancy, through embryo transfer, in one of the 19 southern white rhinos that live at the Ol Pejeta Conservancy. But even if a sufficient number of eggs were gathered from the endangered females, embryo transfer between species is rarely successful. Another option is In vitro fertilization — but the remaining northern white rhino females are not physically able to carry a pregnancy to term. And finally, you could turn northern white rhino stem cells into sperm and eggs. But this option would take much more research, which could take years.

White rhinos have a life expectancy of 40-50 years, and so we are racing against time to save this species.

Cofactor Genomics was called by the San Diego Zoo to aid in the race to save the northern white rhino. We will use our decades of experience working on important genome projects (including The Human Genome Project) to sequence the DNA and analyze the genomes of 13 rhino samples. “The northern white rhinoceros genetic rescue project is an amazing example of San Diego Zoo’s global commitment to fight extinction. We are pleased to have the involvement of the team at Cofactor Genomics as we undertake the first whole genome studies of the northern white rhinoceros,” states Oliver Ryder, Director of Genetics at San Diego Zoo Institute for Conservation Research.

The genome sequence produced by Cofactor will be used to determine the divergence and similarity between the northern and southern white rhinos. This will tell us the probability of success for cross species embryogenesis.

As future scientific advances are made, having the rhino’s genome sequence may make it possible to edit the genome of a closely related species into that of an extinct species. The recent discovery of the CRISPR/Cas9 system could make this type of editing possible once the system is refined enough to work across whole genomes.

At Cofactor, we realize very few people have the opportunity to affect the extinction of a species and are proud to be a part of this important effort.

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