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How multidimensional gene expression models lead to improved analyses and outcomes.

We build Health Expression Models (HEMs) to interpret dynamic, complex data that define health state.


The World’s Largest Database of RNA Profiles.

We have built models of disease from over 10,000 patient samples. To understand the key drivers of disease, we encode the RNA of each patient sample and compare that sample to our disease models.   We model thousands of samples, in hundreds of diseases, to provide one answer.

Clinically Approved RNA Diagnostics

We have spent years working closely with regulatory agencies in order to meet the stringent requirements necessary to apply our technologies to clinical samples. Our lab is CAP/CLIA certified, allowing us to process clinical samples.


Health Expression Models (HEMs) are quantitative, global representations of gene expression that define health state. We apply the HEMs in our Prism database to go beyond gene expression profiling and provide actionable insights for understanding disease.

Prism is our proprietary database of Health Expression Models (HEMs). You can access Prism through one of our disease-specific assays, such as ImmunoPrism™ — an RNA-based immune profiling assay which enables a unique look into an oncology patient’s immune cell biomarkers. The assay applies our immune-specific HEMs to interpret the tumor microenvironment.

ImmunoPrism™ is offered as a reagent kit with cloud-based informatics which enables access to our Prism database for analysis. You can also work with our team of scientific experts to have your samples analyzed in our CAP/CLIA laboratory.


“While others have been looking at DNA, our team has been heavily focused on developing technologies suited for RNA. Specific methods and technologies are required for RNA because of the dynamic nature of the molecules.”

– Jon Armstrong, CSO Cofactor

For Research Use Only – not for use in clinical or diagnostic procedures.

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