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Products that unlock the power of RNA.

Our products represent years of development advancing the science of RNA to enhance clinical research and diagnostics.


Cofactor ImmunoPrism™ delivers improved tumor marker analysis and biological insights for immune-oncology using machine-learning based expression models.

By building our expression models from the ground up, we’ve created a new way of looking at biology — with greater resolution and depth than individual signatures or gene expression markers. These models are pathway agnostic and rely on the dynamic nature of RNA to define what makes a patient, cell type, or disease unique.

While most assays stop at the delivery of data, our ImmunoPrism™ assay provides actionable biomarkers that can predict responses to drug therapy and help you make critical clinical decisions.

Data from each patient cohort is analyzed using our proprietary Prism database of HEMs to provide an individual report summarizing the immune profile of each patient. Additionally, it generates a report which highlights biomarkers and the statistics that define each cohort.


ImmunoPrism Assay
ImmunoPrism Assay

Submit patient materials directly to our scientific experts and gain access to our CAP/CLIA laboratories. We’ll deliver an ImmunoPrism™ report that provides insights into the complex dynamic between the tumor and the immune system. You’ll receive the predictive biomarkers you need to propose tumor-infiltrating lymphocytes (TILs) biomarkers for immune-oncology drugs that can make a bigger difference.

Combine our technology and technical experts with your samples to support your translational study.

ImmunoPrism Kit
ImmunoPrism Kit

Receive the ImmunoPrism™ kit and use your own sequencing resources to gain access to the same technology utilized in our laboratories to derive your patients’ immune score. You’ll receive robust biomarkers and detailed insights in a fully-analyzed and easy-to-interpret report that eliminates the need for further bioinformatic or statistical analysis.

You can also choose to add on our user-friendly Extraction Kit optimized to provide the highest quality and quantity of total RNA from FFPE tissues for input into the ImmunoPrism™ assay.

Product NameCatalog NumberDescriptionList Price
ImmunoPrism Assay – RUOCFGDX-301Cofactor ImmunoPrism Assay – Research Use Only$1,900
ImmunoPrism Assay – CAPCFGDX-302Cofactor ImmunoPrism Assay – Clinically-validated$2,920
ImmunoPrism Kit – 8 reactionCFGK-301Cofactor ImmunoPrism Immune Profiling Kit – 8 reactions$4,792
ImmunoPrism Kit – 24 reactionCFGK-302Cofactor ImmunoPrism Immune Profiling Kit – 24 reactions$13,176
Prism Extraction KitCFGK-401Cofactor Prism FFPE Extraction Kit – 24 samples$250

“Our database of Health Expression Models (HEMs) is providing insights beyond what was previously possible in the tumor microenvironment.”

– Dr. Jarret Glasscock, CEO

  • Accepts RNA from all solid tumor types with inputs as low as 20 ng.
  • Delivers fully-analyzed biomarker discovery report with quantitative immune cell characterization – enabling intra and inter sample comparisons.
  • Unique biomarker analysis delivers most predictive markers in defined sample cohort (responders/non-responders, pre/post-treatment, stage, etc).
  • Enables high-throughput analysis of TILs and escape genes from FFPE.
  • Only 20 ng of RNA input required.
  • As few as two FFPE sections required.
  • Accepts all solid tumor tissues including fresh, frozen, FFPE or previously extracted RNA.
Save Time & Money

We’ve invested in optimizing workflows and building databases so you don’t have to. Receive a full biomarker analysis with quantitative characterization including statistics and multidimensional data that’s both cost-effective and time-sensitive.

Quality Matters

We’ve got your most challenging samples covered, including all solid tumor types with inputs as low as 20 ng. Receive timely, reliable and precise data from scientists who are always on the verge of innovation. And get hands-on support from a team that’s focused on your needs.

Accuracy Counts

Our signature molecular and analysis tools, paired with our HEMs database enables higher specificity of difficult-to-analyze cell types. So we can deliver more accurate, sensitive and actionable biomarker results.

ImmunoPrism Assay Report

ImmunoPrism Assay Report

Our ImmunoPrism™ assay reports on the most impactful immune modulatory molecules demonstrated to have implications in drug discovery, biomarker development, and immunotherapy efficacy monitoring.

Featured Immune Cells & Escape Genes

Featured Immune Cells & Escape Genes

Immune Cells: CD4+ T cells, CD8+ T cells, CD19+ B cells, CD14+ Monocytes, CD56+ NK cells, M1 Macrophages, M2 Macrophages, Treg cells

Escape Genes: PD-1, PD-L1, CTLA4, OX40, TIM-3, BTLA, ICOS, CD47, IDO1, ARG1

Don’t see your gene or immune marker of interest?

ImmunoPrism Data Sheet

ImmunoPrism Data Sheet

Download the Data Sheet with validation data and applications.

Access to Prism Portal

Access to Prism Portal

Ready to upload your data for analysis?

Find Robust Biomarkers

Find Robust Biomarkers

Discover Multidimensional Biomakers with powerful predictive accuracy.

The ImmunoPrism™ assay was developed and characterized by Cofactor Genomics in San Francisco, CA.  ImmunoPrism™  reagents are for Research Use Only and not for use in diagnostics procedures.  The results of the included report are generated by a specific ImmunoPrism™  Version and are subject to change in future releases.  Gene expression levels of escape genes are calculated for the sample in comparison to mean expression across various cancers.  Immune profiling in ImmunoPrism™  has been shown to significantly correlate with flow cytometry measurements for PBMC samples across 5 different immune cell types.  In addition, ImmunoPrism™  immune profiling has also shown to be consistent across fresh-frozen and formalin-fixed samples.  Furthermore, ImmunoPrism™  immune profiling has been validated in dissociated tumor cells.  For technical support or additional information on assay performance or validation, please contact: [email protected].


Cofactor’s ImmunoPrism™  Assay is offered both for Research Use Only (not to be used as a diagnostic assay) and as a CAP-validated assay.  Please contact us to discuss which option is right for your application.

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