PINNACLE
Interested in learning how Pinnacle can help add value to your clinical research?
Unprecedented Perspective for Personalized Medicine
Uncover gene expression and
fusion patterns that make each
patient’s cancer unique.
Analyze over 300 oncology-relevant
targets from a single FFPE sample,
while gaining context from hundreds of
other samples of the same cancer type.
Why RNA?
RNA is increasingly recognized as a crucial class of cancer biomarkers. The presence and quantity of RNA is a snapshot of the state of a sample or cell at a given moment in time and therefore gives unique insight into the disease biology. Expression signatures, transcript fusions, and novel isoforms have all been valuable in identifying important patient segments that correspond to response to therapy or for identifying new drug targets.
Ready to learn more?
Download our recent webinar featuring Dr. Eric Duncavage, Pathologist at Washington University's Genomic Pathology Services core, and learn about how RNA adds valuable information missed by DNA assays alone.
Why Pinnacle?
Cofactor Pinnacle enables the identification of important cancer associated features, not detectable by DNA sequencing alone. Pinnacle measures the RNA expression of 379 prominent cancer genes, identifies those with oncogenic expression, and enables fusion identification in 187 critical cancer associated genes from FFPE tumor samples.
What are the Benefits?
Expression signals from Cofactor's Pinnacle are queried against a cancer knowledge base to:
- Identify driver genes with oncogenic overexpression
- Validate the expression and prioritize previously identified DNA variants, such as CNVs and SNPs
- Establish the presence of cancer related fusion transcripts
This information provides researchers unprecedented insight into disease subtypes across sample groups, helps them identify markers of efficacy and/or safety, and ultimately offers the power to identify new drug targets and pathways.
The Cofactor Pinnacle Report summarizes your data into an efficient format that provides a visually impactful interpretation of the meaningful features from your sample.
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