October 2, 2014

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In RNA-Seq Posted

The Latest in RNA-Seq — What You Need to Know

This month much of the discussion in the RNA-Seq world has centered on a group of papers just published in Nature Biotechnology. Two large research consortia and affiliated research teams undertook large-scale RNA-Seq studies evaluating the major sequencing platforms, library protocols, normalization methods, and spike-in controls. Taken together, the papers establish the current state of the field, determining the true […]
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In RNA-Seq, Sequencing Posted

Exosome RNA-seq – A Primer

Exosomes are a type of membranous vesicle derived from cells and released into the extracellular space. They are generally 30-100 nm in diameter, containing nucleic acid and protein, and can serve as transporters of these materials from cell to cell. Exosomes are released by all cultured cell types and have also been found in biofluids […]
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In Cofactor Genomics, News Posted

Cofactor Awarded NHGRI/NHLBI Contract

September 2014, The National Heart, Lung, and Blood Institute (NHLBI) and National Human Genome Research Institute (NHGRI) has awarded a contract to Cofactor Genomics to identify sites of epigenetic modifications contributing to cardiovascular disease endpoints such as resistant hypertension and coronary calcification across a large cohort. This work will support the goals of the NHGRI/DIR Cardiovascular Disease Section (CDS) and […]
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In News Posted

Cofactor Genomics Awarded NIH Grant to Develop a Circular RNA Enrichment Kit and Reference Profile

August 2014, Cofactor Genomics has been awarded a grant by the National Institute of Mental Health (NIMH), an institute of the NIH, to develop a standardized enrichment kit and define the normal reference profile for circular RNAs (circRNA) in the nervous system. These types of products could prove critical in advancing studies focused on neuronal development, […]
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In Analysis, RNA-Seq, Sequencing Posted

1 graph that will give you a new perspective on your sequencing experiment

You’ve heard us talk plenty of times before on this blog about saturation curves. We generate them for every project because they’re incredibly powerful in helping to understand a sequencing experiment. To that end, I thought I’d walk through several specific examples to give you an inside look at how we interpret saturation curves. Here is a […]
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In Uncategorized Posted

DNA Methylation – A Primer

In my last blog I began a discussion on the many different DNA and RNA modifications that can modulate gene expression as part of a complex system. Over the next few blog posts I will be continuing this conversation, and today I will focus on DNA methylation. First, what is methylation? Well, it is a structural change, […]
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