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Cofactor has developed new technologies and products to lead the way in the agricultural genomics revolution through its Bench To Barnyard services and products.
Read more about Bench To Barnyard
Bench-to-Barnyard
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Cofactor has developed new technologies and products to lead the way in the agricultural genomics revolution through its Bench To Barnyard services and products.
Read more about Bench To Barnyard
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Introduction
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Cofactor Genomics is introducing new bovine exome capture products and services to assist researchers in their investigation of variations across any breed of beef and dairy cattle.
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World’s First Bos taurus Exome Capture Product
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Cofactor Genomics anounced today the release of services using a new product allowing researchers to selectively enrich, sequence, analyze and detect variants in coding and regulatory regions of the Bovine (cow) genome. This will permit researchers to investigate and discover variation across any breed of beef and dairy cattle and will accelerate the pace of scientific research and discoveries for one of the world’s largest food sources.
Cofactor Genomics collaborated with members of the Bos taurus community and the USDA, who provided mRNA and EST data, to design probes to capture the most comprehensive set of coding and regulatory regions possible. Cofactor utilized the Bos taurus assembly from the Center for Bioinformatics and Computational Biology at University of Maryland, called UMD3.1, as the foundation for the development of their in-solution capture product.
The exome capture strategy will allow researchers to selectively pull-down and sequence approximately 46 Mb of the cow genome for hypothesis-neutral marker and haplotype analysis as well as study and selectively breed for disease resistance, carcass quality, and palatability. Cofactor is capable of providing hybridization, library generation, sequencing, analysis, and visualization services for all samples and will begin accepting orders in early December.
Current research methods leverage technologies that require prior knowledge of genomic variation. These methods include genotyping arrays consisting of SNP’s gathered from Bovine HapMap and other sources and small-scale PCR to assess variation in a small number of genomic regions. In contrast, Cofactor’s product will provide sequence-verified SNP’s, insertions, and deletions, without any prior knowledge of genomic variation, at single-base resolution.
Dr. Jarret Glasscock, CEO and founder of Cofactor Genomics, commented, "The development of an in-solution whole-exome capture strategy for Bos taurus will further allow agricultural researchers to investigate and discover causative variation in cattle, at unparalleled resolution. This product will also allow researchers to probe the UTR and coding regions of the cow genome without spending money to sequence repetitive areas of the genome. Cofactor is excited to lead the way in this agricultural genomics revolution through our Bench To Barnyard™ products and services.”
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Partnership with Intrepid Bioinformatics provides visualization
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Cofactor Genomics, a leader in plant and animal genomic research, announced today a partnership with Intrepid Bioinformatics of Louisville, Kentucky, to enhance Cofactor’s recently released Bovine whole-exome capture product. The partnership represents a key component of Cofactor’s Bench to BarnyardTM line of products and services, forming an end-to-end solution for researchers to quantify, discover, and visualize genomic variation from the cow genome. Intrepid Bioinformatics’ data management system will provide a secure, intuitive interface to variants generated from Cofactor’s whole-exome capture product and will be offered to Cofactor’s Bovine capture customers.
Cofactor Genomics recently released the world’s first Bovine whole-exome capture product, which enables researchers to selectively enrich, sequence, analyze and detect variants in coding and regulatory regions of the cow genome. Intrepid Bioinformatics’ SNP data service allows researchers to load and examine their data down to the sequence read while viewing polymorphisms, exons and introns, allele frequencies, and more. The pairing of Intrepid’s visualization solutions and Cofactor’s design and analysis capabilities offers researchers an unprecedented front-to-back solution for the discovery, characterization, and visualization of causative variation and hypothesis-neutral haplotype and marker analysis across any breed of beef and dairy cattle.
Jon Armstrong, chief operating officer of Cofactor Genomics, commented, “Each of our respective companies has developed advanced genomic tools and services that, when combined, represent an unparalleled solution for moving from phenotype to genotype. Cofactor’s scientists are excited to team with the experts at Intrepid Bioinformatics who are similarly driven to provide products and tools which inspire amazing science in the agricultural community.”
Dr. Ted Kalbfleisch, chief executive officer of Intrepid Bioinformatics reported, “Cofactor Genomics’ whole-exome capture product will be a powerful tool for the Bovine research community. We are pleased to partner with them to provide the data management complement for this important new resource.”
Cofactor Genomics and Intrepid Bioinformatics will be showcasing the new Bovine exome-capture product and viewer at the Plant and Animal Genome XX Conference January 14-18 in San Diego. Cofactor is exhibitor 532 and Intrepid Bioinformatics is exhibitor 405.
About Cofactor Genomics, LLC
Cofactor Genomics is a privately held biotechnology company that employs experimental design, next-generation sequencing, and proprietary analysis technology and pipelines to drive the discovery and design of new products and processes for the life sciences field. Cofactor’s D&ATM (Design & Analysis) Solution is constructed to specifically assist those researchers who require more than just sequencing at a reasonable cost. It also provides expert design and analysis capabilities, customized to specific requirements, and bioinformatics to make the most of the data that is generated. Cofactor’s expertise in molecular biology and bioinformatics accelerates its partners’ biological research, discovery and product development in a number of scientific areas worldwide. For more information, visit www.cofactorgenomics.com.
About Intrepid Bioinformatics, Inc.
Intrepid Bioinformatics helps achieve meaningful use of genetic information by offering an interoperable repository that supports NGS, SNP and genotype data. Intrepid’s system reduces the amount of time spent organizing, querying and analyzing data, maintaining complex data management systems, integrating analytical programs, and sharing data with collaborators. The system allows data to be uploaded using either a simple drag-and-drop interface or programmatically through an open API. After upload, Intrepid’s genome browser allows users to immediately view mappings of repeat sequences, polymorphisms, coding sequences, allele and genotype frequencies, and much more. Data can then be analyzed more quickly – and entire populations can be studied and compared all at once – through a highly secure database. For more information, visit www.intrepidbio.com.
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Bovine Exome Capture Product Literature
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